P53 tumor suppressor factor, plasminogen activator inhibitor, and vascular endothelial growth factor gene polymorphisms and recurrent implantation failure  

Oleh:

Goodman, Cammi ; Jeyendran, R.S. ; Coulam, C.B.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 92 no. 02 (Aug. 2009), page 494-498.
Topik: P53 tumor suppressor factor; plasminogen activator inhibitor; vascular endothelial growth factor; gene polymorphisms; recurrent pregnancy loss

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2009.03 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective : To examine whether a panel of gene polymorphisms, including p53 codon 72 tumor suppressor factor, plasminogen activator inhibitor 1 (PAI-1), and vascular endothelial growth factor (VEGF) -1154, are risk factors for implantation failure after IVF-ET. Design : Case-control study. Setting : Private laboratories and reproduction medical centers. Patient(s) : Seventy women with history of recurrent implantation failure after IVF-ET and 73 fertile control women. Intervention(s) : Buccal swabs were obtained from all participants. The DNA was extracted from the buccal swabs and analyzed for the presence of the PAI 4G/4G, VEGF -1154A/A, and p53 codon 72 Arg/Pro genotypes. Main Outcome Measure(s) : The prevalence of homozygous p53 Pro72, PAI 4G/4G, and VEGF -1154A/A was compared between women experiencing recurrent implantation failure and fertile control women. Result(s) : The frequencies of homozygous p53 Pro72, PAI 4G/4G, and VEGF -1154AA were significantly higher among women experiencing implantation failure compared with control women. Conclusion(s) : A panel of tests for p53 codon 72 Pro/Pro, PAI-1 4G/4G and VEGF -1154A/A may be useful to identify women at risk for implantation failure after IVF-ET.

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