Intrafollicular antimüllerian hormone levels predict follicle responsiveness to follicle-stimulating hormone (FSH) in normoandrogenic ovulatory women undergoing gonadotropin releasing-hormone analog/recombinant human FSH therapy for in vitro fertilization and embryo transfer  

Oleh:

Dumesic, Daniel A. ; Lesnick, Timothy G. ; Stassart, Jacques P. ; Ball, G. David ; Wong, Ashley ; Abbott, David H.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 92 no. 01 (Jul. 2009), page 217-221.
Topik: Antimüllerian hormone; müllerian-inhibiting substance; intrafollicular steroidogenesis; E2; IVF-ET

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2009.03 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective : To investigate the relationship between antimüllerian hormone (AMH) and steroidogenesis in follicles of normoandrogenic ovulatory women undergoing follicle-stimulating hormone (FSH) therapy for in vitro fertilization/embryo transfer (IVF-ET). Design : Prospective cohort. Setting : Institutional/private practice. Patient(s) : 26 normoandrogenic ovulatory women. All women received gonadotropin-releasing hormone (GnRH) analog and ovarian stimulation for IVF-ET. Intervention(s) : Follicle fluid was aspirated at oocyte retrieval from the first follicle of each ovary. Main Outcome Measure(s) : Follicle fluid was assayed for AMH, estradiol (E2), progesterone, androstenedione, testosterone, dihydrotestosterone, insulin, and FSH. Result(s) : Intrafollicular AMH levels positively and negatively correlated with E2 and FSH concentrations in follicles, respectively, causing a positive relationship between follicle fluid AMH levels and E2/FSH ratios as a measure of follicle sensitivity to FSH. A positive relationship also existed in follicles between AMH levels and E2/androgen ratios as a marker of aromatase activity. Conclusion(s) : The AMH levels in follicles of IVF patients positively correlate with follicle sensitivity to FSH.

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