Preimplantation aneuploidy testing for infertile patients of advanced maternal age: a randomized prospective trial  

Oleh:

Schoolcraft, William B. ; Katz-Jaffe, Mandy G. ; Stevens, John ; Rawlins, Mary ; Munne, Santiago

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 92 no. 01 (Jul. 2009), page 157-162.
Topik: Preimplantation aneuploidy testing; chromosomal aneuploidy; AMA

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2009.03 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective : To assess the potential benefit of preimplantation aneuploidy testing on the outcome of in vitro fertilization (IVF) for women of advanced maternal age (AMA). Design : Prospective randomized clinical trial. Setting : Private IVF clinic. Patient(s) : Sixty-two infertile AMA couples undergoing fertility treatment. Intervention(s) : Fluorescent in situ hybridization (FISH) for chromosomes X, Y, 13, 15, 16, 17, 18, 21, and 22. Main Outcome Measure(s) : Preimplantation aneuploidy testing of biopsied blastomeres on day 3 of development. Result(s) : Fertilization and blastocyst developmental rates were similar for the test and control groups: 80% versus 77.4% and 49% versus 48.2%, respectively. The average number of embryos transferred was comparable at 2.2 for the test group and 2.7 for the control group. Implantation rates were also equivalent across the two groups: 37.3% in the control group versus 36.5% in the test group. Nevertheless, the spontaneous abortion rate was observed to be lower for the test group: 25.9% versus 32.26% in the control group. This resulted in an observed increase in delivery rates for the test group: 78% versus 67.74% in the control group. Conclusion(s) : Preimplantation aneuploidy testing does not appear to statistically significantly improve outcome parameters in infertile AMA patients; however, a trend toward a decrease in the spontaneous abortion rate with a subsequent higher delivery rate was observed.

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