Association of estrogen receptor alpha and interleukin-10 gene polymorphisms with endometriosis in a Chinese population  

Oleh:

Jingyan, Xie ; Shukui, Wang ; Bangshun, He ; Yuqin, Pan

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 92 no. 01 (Jul. 2009), page 54-60.
Topik: Endometriosis; estrogen receptor a; interleukin-10; gene polymorphism

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2009.03 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective : To determine whether polymorphisms of the estrogen receptor a (ERa) and interleukin-10 (IL-10) genes are associated with endometriosis in a Chinese population. Design : Association study. Setting : University hospital. Patient(s) : Chinese women diagnosed with endometriosis by laparotomy or laparoscopy. Intervention(s) : Determination of polymorphisms of the ERa and IL-10 genes was performed by polymerase chain reaction and restriction fragment length polymorphism analysis in 214 affected women and 160 controls. Main Outcome Measure(s) : Frequency and distribution of PvuII and XbaI polymorphisms of ERa and of BslI, SspI, and RsaI polymorphisms of IL-10. Result(s) : There was no significant difference between the endometriosis patients and the control groups in the genotype frequency of ERa-PvuII and promoter of IL-10 gene polymorphisms in the position of -1082. However, the frequency of ERa-XbaI and -592 or -819C alleles of IL-10 in the endometriosis group was significantly higher than that of controls, and further analysis showed that the X allele of ERa-XbaI was associated with endometriosis. Conclusion(s) : The X allele of ERa-XbaI and the -592 or -819 C allele of IL-10 are associated with endometriosis.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali