Long-term safety and tolerability of flutamide for the treatment of hirsutism  

Oleh:

Castelo-Branco, Camil ; Moyano, Dolores ; Gomez, Olga ; Balasch, Juan

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 91 no. 04 (Apr. 2009), page 1183-1188.
Topik: Safety; tolerability; adverse effects; flutamide; hirsutism; hyperandrogenism

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2009.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective : To evaluate the long-term safety and tolerability of flutamide therapy for hirsutism. Design : Prospective observational study. Setting : Gynecology department in a teaching hospital. Patient(s) : Hyperandrogenic women presenting for hirsutism treatment were followed between January 2000 and January 2007. Intervention(s) : Women received flutamide 250 mg/day alone (n = 27) or combined with a fixed dose of an oral contraceptive containing 0.020 mg of ethinyl estradiol (EE) and 0.15 mg of desogestrel (n = 56). Main Outcome Measure(s) : Adverse events, safety, tolerability and efficacy were assessed every 6 months during the follow-up. Liver and lipid profiles were also recorded. Result(s) : Patients under flutamide therapy showed, compared with basal values, a significant progressive decrease in hirsutism scores after 6 months of treatment with a maximum effect at 12 months that was maintained during the 84 months of follow-up. A total of 40.96% women presented one or more adverse effects during the follow-up; 33.73% showed at least one adverse effect possibly related with the study drug, and 24.09% withdrew from the study because of adverse effects. During the follow-up, as many as 59% of patients abandoned the study. Conclusion(s) : Flutamide is very effective for hirsutism treatment; however, adverse effects are very frequent and associated with low long-term compliance.

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