Comparison of hormonal and metabolic markers after a high-fat, Western meal versus a low-fat, high-fiber meal in women with polycystic ovary syndrome  

Oleh:

Katcher, Heather I. ; Kunselman, Allen R. ; Dmitrovic, Romana ; Demers, Laurence M.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 91 no. 04 (Apr. 2009), page 1175-1182.
Topik: insulin resistance; hyperandrogenism; postprandial; testosterone; fiber

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2009.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective : To determine the effect of meal composition on postprandial T levels in women with polycystic ovary syndrome (PCOS). Design : Randomized, crossover design. Setting : Academic research center. Patient(s) : Fifteen women with PCOS. Intervention(s) : We evaluated changes in T, sex hormone binding globulin (SHBG), DHEAS, cortisol, glucose, and insulin for 6 hours after a high-fat, Western meal (HIFAT) (62% fat, 24% carbohydrate, 1 g fiber) and an isocaloric low-fat, high-fiber meal (HIFIB) (6% fat, 81% carbohydrate, 27 g fiber). Main Outcome Measure(s) : Change in T levels. Result(s) : Testosterone decreased 27% within 2 hours after both meals. However, T remained below premeal values for 4 hours after the HIFIB meal and 6 hours after the HIFAT meal. Insulin was twofold higher for 2 hours after the HIFIB meal compared with the HIFAT meal. Glucose was higher for 1 hour after the HIFIB meal compared with the HIFAT meal. DHEAS decreased 8%–10% within 2–3 hours after both meals, then increased during the remainder of the study period. Cortisol decreased during the 6-hour period after both meals. Conclusions : Diet plays a role in the regulation of T levels in women with PCOS. Further studies are needed to determine the role of diet composition in the treatment of PCOS.

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