Excessive ovarian response is associated with increased expression of interleukin-2 in the periimplantation endometrium  

Oleh:

Makkar, Guneet ; Yu Ng, Ernest Hung ; Yeung, William Shu Biu ; Pak, Chung Ho

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 91 no. 04 (Apr. 2009), page 1145-1151.
Topik: Cytokines; endometrium; excessive responders; implantation; estradiol

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2009.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective : To evaluate and compare in vivo expression of T helper type 1 (Th1) cytokines in the peri-implantation endometrium of infertile patients between natural and stimulated cycles. Design : An observational study. Setting : A tertiary assisted reproduction center. Patient(s) : Infertile patients. Intervention(s) : Uterine flushings and endometrial biopsies were collected 7 days after LH surge in natural cycles or after hCG injection in stimulated cycles. Main Outcome Measure(s) : T helper type 1 cytokines were determined by immunolocalization and by ELISA. Result(s) : Natural cycles were classified as group A (n = 17), whereas stimulated cycles with peak serum E2 of =20,000 pmol/L (moderate responders) and with peak serum E2 of >20,000 pmol/L (excessive responders) were classified as group B (n = 32) and group C (n = 32), respectively. Higher serum E2 concentration was associated with increased expressions of interleukin (IL)-2 in the endometrium and uterine flushing. Group C demonstrated a statistically significantly higher IL-2 expression in endometrial biopsies by glandular and stromal immunostaining and by ELISA, compared with group A and group B. There was no difference in IL-2 concentration between group A and group B. Interferon-? protein concentration was comparable for the three groups. Conclusion(s) : Increased expression of IL-2 in the peri-implantation endometrium may account for the lower implantation rate in excessive responders.

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