Consanguinity and family clustering of male factor infertility in Lebanon  

Oleh:

Inhorn, Marcia C. ; Kobeissi, Loulou ; Nassar, Zaher ; Lakkis, Daad ; Fakih, Michael H.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 91 no. 04 (Apr. 2009), page 1104-1109.
Topik: Male infertility; consanguinity; inbreeding; recessive genetic disorders; Lebanon; Middle East; Muslim world

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2009.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective : To investigate the influence of consanguineous marriage on male factor infertility in Lebanon, where rates of consanguineous marriage remain high (29.6% among Muslims, 16.5% among Christians). Design : Clinic-based, case-control study, using reproductive history, risk factor interview, and laboratory-based semen analysis. Setting : Two IVF clinics in Beirut, Lebanon, during an 8-month period (January–August 2003). Patient(s) : One hundred twenty infertile male patients and 100 fertile male controls, distinguished by semen analysis and reproductive history. Intervention(s) : None. Main Outcome Measure(s) : Standard clinical semen analysis. Result(s) : The rates of consanguineous marriage were relatively high among the study sample. Patients (46%) were more likely than controls (37%) to report first-degree (parental) and second-degree (grandparental) consanguinity. The study demonstrated a clear pattern of family clustering of male factor infertility, with patients significantly more likely than controls to report infertility among close male relatives (odds ratio = 2.58). Men with azoospermia and severe oligospermia showed high rates of both consanguinity (50%) and family clustering (41%). Conclusion(s) : Consanguineous marriage is a socially supported institution throughout the Muslim world, yet its relationship to infertility is poorly understood. This study demonstrated a significant association between consanguinity and family clustering of male factor infertility cases, suggesting a strong genetic component.

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