Clinical efficacy of highly purified urinary FSH versus recombinant FSH in volunteers undergoing controlled ovarian stimulation for in vitro fertilization: a randomized, multicenter, investigator-blind trial  

Oleh:

Baker, Valerie L. ; Fujimoto, Victor Y. ; Kettel, L. Michael ; Adamson, David ; Hoehler, Fred ; Jones, Clarence E. ; Soules, Michael R.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 91 no. 04 (Apr. 2009), page 1005-1011.
Topik: IVF; clinical outcome; highly purified urinary FSH; recombinant FSH; pregnancy

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2009.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective : To compare the efficacy of highly purified human urinary follicle stimulating hormone (HP-hFSH) versus human recombinant follitropin-alpha (rFSH) in volunteers undergoing controlled ovarian stimulation for IVF. Design : A randomized, controlled, investigator-blind trial. Setting : Four assisted reproductive technology centers. Patient(s) : One hundred fifty-two IVF patients. Intervention(s) : Volunteers, aged 18–39, were randomized to HP-hFSH (n = 76) versus rFSH (n = 76) at a starting dose of 300 IU in down-regulated cycles. Main Outcome Measure(s) : Number of oocytes, clinical pregnancy rate, and live birth rate with HP-hFSH versus rFSH. Result(s) : The total IU of gonadotropin used did not differ between the two groups. There was no difference in number of oocytes retrieved with HP-hFSH (mean = 16.3) compared with rFSH (mean = 17.1), confidence interval (CI) of difference = -3.79 to +2.18. Clinical pregnancy rate, as defined by the presence of a gestational sac, was 48.7% (CI = 37.0%–60.4%) with HP-hFSH versus 44.7% (CI = 33.3%–56.6%) with rFSH (CI of difference = -11.9% to +19.8%). Live birth rate was 38.2% (29 of 76) in both groups (CI = 27.2%–50.0%), for a difference between groups of 0.0% (CI of the difference = -15.4% to +15.4%). Conclusion(s) : There were no statistically significant differences in mean oocyte number, clinical pregnancy rate, or live birth rate between HP-hFSH versus rFSH.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali