Pathophysiologic features of “thin” endometrium  

Oleh:

Miwa, Ichiro ; Tamura, Hiroshi ; Takasaki, Akihisa ; Yamagata, Yoshiaki ; Shimamura, Katsunori ; Sugino, Norihiro

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 91 no. 04 (Apr. 2009), page 998-1004.
Topik: Endometrium; blood flow; angiogenesis; VEGF

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2009.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective : To characterize pathophysiologic features of a “thin” endometrium. Design : A prospective observational study. Setting : University Hospital and City General Hospital. Patient(s) : Patients with normal-thickness endometrium (Normal-Em group: endometrial thickness =8 mm; n = 57) and thin endometrium (Thin-Em group: endometrial thickness <8 mm; n = 17). Main Outcome Measure(s) : Blood flow impedance of the uterine radial artery (RA) was assessed as resistance index (RI) by transvaginal color-pulsed Doppler ultrasonography. The area of glandular epithelium, the number of blood vessels, and vascular endothelial growth factor (VEGF) expression were examined in the midluteal-phase endometrium. Result(s) : The RA-RI in the Thin-Em group was significantly higher than in the Normal-Em group throughout the menstrual cycle. Endometrial thickness was significantly correlated with RA-RI. Growth of glandular epithelium, the number of blood vessels, and VEGF expression were significantly lower in the Thin-Em group than in the Normal-Em group. Conclusion(s) : A “thin” endometrium was characterized by high blood flow impedance of RA, poor epithelial growth, decreased VEGF expression, and poor vascular development.

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