Developmental Origins of Adult Disease  

Oleh:

Simmons, Rebecca A.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Pediatric Clinics of North America vol. 56 no. 03 (Jun. 2009), page 449-466.
Topik: Advances in Neonatology

Ketersediaan

Perpustakaan FK Nomor Panggil: P13.K.2009.03 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Intrauterine growth retardation (IUGR) has been linked to development of type 2 diabetes in adulthood. Using a rat model, we tested the hypothesis that uteroplacental insufficiency disrupts the function of the electron trans¬port chain in the fetal 3-cell and leads to a debilitating cascade of events. The net result is progressive loss of 13-cell function and eventual develop¬ment of type 2 diabetes in the adult. Studies in the IUGR rat demonstrate that an abnormal intrauterine environment induces epigenetic modifica¬tions of key genes regulating 13-cell development; experiments directly link chromatin remodeling with suppression of transcription. Future research will be directed at elucidating the mechanisms underlying epige-netic modifications in offspring.

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