A randomized placebo-controlled study on the effects of pioglitazone on cortisol metabolism in polycystic ovary syndrome  

Oleh:

Glintborg, Dorte ; Hermann, Anne Pernille ; Hagen, Claus

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 91 no. 03 (Mar. 2009), page 842-850.
Topik: PCOS; PPAR-?; cortisol; steroid metabolites; adiponectin; insulin sensitivity; free fatty acids; growth hormone; IGF-I

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2009.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective To investigate possible effects of insulin-sensitizing treatment on cortisol metabolism in insulin-resistant patients with polycystic ovary syndrome (PCOS). Design Randomized placebo-controlled study. Setting Academic tertiary care medical center. Patient(s) Thirty insulin-resistant PCOS patients. Intervention(s) Sixteen weeks of pioglitazone (30 mg/day) or placebo treatment. Main Outcome Measure(s) Twenty-four-hour 20 min integrated blood sampling for measurement of cortisol and 24 h urinary excretion of steroid metabolites. Relative 5a-reductase activity was evaluated by allotetrahydrocortisol (alloTHF)/THF and androsterone/etiocholanolone (A/E) ratios. Delta values denoted changes during the treatment period (16 weeks - basal). Pyridostigmine growth hormone (GH) stimulation tests were performed, and testosterone (T), dihydrotestosterone (DHT), DHEA, DHEAS, adiponectin, and insulin-like growth factor I (IGF-I) were measured before and after intervention. Result(s) Insulin sensitivity, GH, adiponectin, and IGF-I significantly increased during pioglitazone treatment, whereas alloTHF/THF levels significantly decreased. Delta alloTHF/THF levels inversely correlated with ? adiponectin levels. ? A/E ratio inversely correlated with ? IGF-I and ? peak GH during GH stimulation tests. No significant changes were measured in T, DHT, DHEA, DHEAS, 24 h mean cortisol, or urinary excretion of steroid metabolites. Conclusion(s) Pioglitazone decreased relative 5a-reductase activity, whereas no significant changes were measured in cortisol levels or urinary cortisol excretion.

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