Detail PPAR-gamma Ligand-binding Activity of Fragrin A Isolated from Mace (the Aril of Myristica fragrans Houtt.) (in Food Sci. Biotechnol. Vol. 17, No. 6) Bibliografi Author: Hwang, Jae-Kwan ; Lee, Jae Young ; Kim, Ba-Reum ; Oh, Hyun In ; Shen, Lingai ; Kim, Naeung Bae Topik: Peroxisome Proliferator-Activated Receptor-gamma (PPAR-gamma); Mace; Myristica fragrans Houtt. (nutmeg); Fragrin A; Type 2 diabetes Bahasa: (EN )    Edisi: May 2008     Penerbit: Korea Institute of Science and Technology Information     Tempat Terbit: Seoul    Tahun Terbit: 2008     Jenis: Article - diterbitkan di jurnal ilmiah internasional Fulltext: 17.6(3)-2007-10-028.pdf (704.86KB; 0 download) Abstract Peroxisome proliferator-activated receptor-gamma (PPAR-gamma), a member of the nuclear receptor of ligand-activated transcription factors, plays a key role in lipid and glucose metabolism or adipocytes differentiation. A lignan compound was isolated from mace (the aril of Myristica fragrans Houtt.) as a PPAR-gamma ligand, which was identified as fragrin A or 2-(4-allyl-2,6-dimethoxyphenoxy)-1-(4-hydroxy-3-methoxyphenyl)-propane. To ascertain whether fragrin A has PPAR-gamma ligand-binding activity, it was performed that GAL-4/PPAR-gamma transactivation assay. PPAR-gamma ligand-binding activity of fragrin A increased 4.7, 6.6, and 7.3-fold at 3, 5, and 10 µM, respectively, when compared with a vehicle control. Fragrin A also enhanced adipocytes differentiation and increased the expression of PPAR-gamma target genes such as adipocytes fatty acid-binding protein (aP2), lipoprotein lipase (LPL), and phosphoenol pyruvate carboxykinase (PEPCK). Furthermore, it significantly increased the expression level of glucose transporter 4 (GLUT4). These results indicate that fragrin A can be developed as a PPAR-gamma agonist for the improvement of insulin resistance associated with type 2 diabetes. Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Lihat Sejarah Pengadaan  Konversi Metadata   Kembali

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