Detail In vitro anti-Malassezia activity of xanthorrhizol isolated from Curcuma xanthorrhiza Roxb (in Letters in Applied Microbiology) Bibliografi Author: Hwang, Jae-Kwan ; Rukayadi, Y. Topik: Anti-Malassezia; In vitro; Malassezia furfur; Malassezia pachydermatis; Xanthorrhizol. Bahasa: (EN )    ISBN: 0266-8254    Edisi: Sep 2006     Penerbit: Society for Applied Microbiology     Tempat Terbit: Bedford    Tahun Terbit: 2006     Jenis: Article - diterbitkan di jurnal ilmiah internasional Fulltext: 5. In vitro anti-Malassezia activity of xanthorrhizol isolated from Curcuma xanthorrhiza Roxb.pdf (532.24KB; 4 download) Abstract Aims: This study aimed at investigating the anti-Malassezia activity of xanthorrhizol (XTZ) isolated from Curcuma xanthorrhiza Roxb. against Malassezia furfur ATCC 14521 and Malassezia pachydermatis ATCC 14522. Methods and Results: The in vitro susceptibility tests for XTZ were carried out in terms of minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC), using broth microdilution method with endpoint after 48 h. Time-kill curves were determined at concentrations ranging from 0 to 25 lg ml)1. The MIC values of XTZ against M. furfur and M. pachydermatis were 1Æ25 and 0Æ25 lg ml)1, respectively. The MFC of XTZ was 5 lg ml)1 for M. furfur and 2Æ5 lg ml)1 for M. pachydermatis. Time-kill curves demonstrated that treatment with 25 lg ml)1 of XTZ for 5 h was able to kill 100% of M. furfur, while 20 lg ml)1 of XTZ for 15 min killed M. pachydermatis completely. Conclusion: XTZ shows potential as an anti-Malassezia agent for inhibiting the growth of M. furfur ATCC 14521 and M. pachydermatis ATCC 14522 in vitro. Significance and Impact of the Study: XTZ may be a useful alternative for treating Malassezia-associated diseases. Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Lihat Sejarah Pengadaan  Konversi Metadata   Kembali

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