Inflammatory Bowel Disease, Stress, and the Endoplasmic Reticulum  

Oleh:

Clevers, Hans

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The New England Journal of Medicine (keterangan: ada di Proquest) vol. 360 no. 07 (Feb. 2009), page 726.

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Perpustakaan FK Nomor Panggil: N08.K.2009.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Full Text PDF PDA Full Text Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited E-mail When Letters Appear PubMed Citation The causes of Crohn's disease and ulcerative colitis are poorly understood, despite having been defined many decades ago on the basis of their clinical manifestations. Experiments involving transgenic mice and genomewide association studies involving patients have independently provided glimpses into the complexity of the genetic causes of these disorders. A recent study described by Kaser and colleagues1 combines experimental and genetic approaches to build a compelling case implicating the unfolded-protein response as a culprit in inflammatory bowel disease. Stress in the endoplasmic reticulum is caused by the accumulation of unfolded nascent proteins in the lumen under adverse cellular conditions. This . . .

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