Impact of Cigarette Smoking on Mortality in HIV-Positive and HIV-Negative Veterans  

Oleh:

Crothers, Kristina ; Goulet, Joseph L. ; Rodriguez-Barradas, Maria C. ; Gibert, Cynthia L. ; Oursler, Kris Ann K. ; Crystal, Stephen ; Goetz, Matthew Bidwell ; Leaf, David A. ; Butt, Adeel A. ; Braithwaite, R. Scott ; Peck, Robin ; Justice, Amy C.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Aids Education and Prevention: An Interdisciplinary Journal vol. 21 no. supp.A (Jun. 2009), page 40-53.
Topik: Cigarette Smoking; HIV-Positive; HIV-Negative Veterans;
Fulltext: AIDS Education and Prevention, 21, Supplement A, 40–53, 2009 (win).pdf (173.63KB)

Ketersediaan

Perpustakaan PKPM Nomor Panggil: A94 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

It is unknown whether smoking confers similar mortality risk in HIV-positive as in HIV-negative patients. We compared overall mortality stratified by HIV and smoking of 1,034 HIV-positive block-matched to 739 HIV-negative veterans, enrolled 2001-2002 in the Veterans Aging Cohort 5 Site Study. Adjusted incidence rate rations (IRR) for mortality were calculated using Poisson regression. Mortality was significantly increased in HIV-positive veterans according to both smoking status and pack-years in unadjusted and adjusted analyses (adjusted IRR 2.31, 95% confidence interval [CI] 1.53-3.49 for HIV-negative current smokers). Comorbid diseases were also significantly increased according to smoking status and pack-years. Current smoking is associated with poor outcomes; even lower levels of exposure appear to be detrimental in HIV-infected veterans. these findings support the need to be detrimental in HIV-infected veterans. These findings support the need for improvements in smoking cessation and for studies of mechanisms and diseases underlying increased mortality in smokers with HIV.

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