Long-term ovarian function and fertility after heterotopic autotransplantation of cryobanked human ovarian tissue: 8-year experience in cancer patients  

Oleh:

Kim, S. Samuel ; Woo, S. Lee

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 91 no. 06 (Jun. 2009), page 2349-2354 .
Topik: Heterotopic transplantation; fertility preservation; ovarian tissue; autotransplantation; cryopreservation; ovarian function; cancer; embryo

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2009.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective To assess the long-term ovarian function and fertility after heterotopic autotransplantion of frozen–thawed ovarian tissue in cancer patients. Design Prospective clinical case series. Setting Academic medical center Patient(s) Four young cancer patients who completed cancer treatment. Intervention(s) Cryopreserved ovarian tissue (2000–2002) was thawed and transplanted to the heterotopic site (between the rectus muscle and fascia) between 2002 and 2005. Main Outcome Measure(s) [1] Serial blood tests (FSH, LH, estradiol, progesterone, testosterone) and ultrasound examinations. [2] Oocyte retrieval and in vitro fertilization. Result(s) The hormonal profiles were consistent with the postmenopausal level before transplantation. The return of the ovarian function was evidenced by hormonal profiles between 12 and 20 weeks after transplantation. Three patients underwent a second transplantation, as restored ovarian function lasted only 3 to 5 months. After the second transplantation, long-term ovarian function (lasting for 15–41 months) was established in all three patients. Six oocytes (one GV, four MI, one MII) were retrieved from the grafts. Three MI oocytes were developed to full maturity in vitro. Four MII oocytes were fertilized and developed to the cleavage stage embryos (up to six-cell). Conclusion(s) Autotransplantation of frozen–thawed ovarian tissue to a heterotopic site restored long-term ovarian function (for >40 months), and showed a potential to restore fertility in cancer patients.

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