Vitamin B-12, apolipoprotein E genotype, and cognitive performance in community-living older adults: evidence of a gene-micronutrient interaction  

Oleh:

Lei, Feng ; Jialiang, Li ; Keng-Bee, Yap ; Ee-Heok, Kua ; Tze-Pin, Ng

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The American Journal of Clinical Nutrition vol. 89 no. 04 (Apr. 2009), page 1263.
Topik: Gene-nutrient interactions

Ketersediaan

Perpustakaan FK Nomor Panggil: A07.K.2009.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Background: The relation between vitamin B-12 and cognitive function in older adults is unclear. Limited evidence suggests that the relation is modulated by apolipoprotein E {epsilon}4. Hence, it is important to further examine this gene-nutrient interaction. Objective: The aim was to investigate the role of apolipoprotein E (APOE) {epsilon}4 as a genetic predisposing factor modulating the effect of vitamin B-12 on cognitive function. Design: A battery of neuropsychological tests, including the Mini-Mental State Examination (MMSE) for global cognition, was administered at the baseline assessment to 539 Chinese adults aged =55 y. The MMSE was repeated at a median 18 mo (n = 376) and a median of 38 mo (n = 247) after baseline. The interaction of vitamin B-12 and APOE {epsilon}4 on cognitive function was examined in a linear mixed-effects model for MMSE and in a multiple linear regression model for neuropsychological test scores. Results: APOE {epsilon}4 was associated with a lower MMSE score. Vitamin B-12 (natural log transformed) was positively related to MMSE score, and this association was much stronger in APOE {epsilon}4 carriers than in APOE {epsilon}4 noncarriers (P for interaction = 0.016). Significant interactions between natural log-transformed vitamin B-12 and APOE {epsilon}4 were also found for the Digit Span Backward Longest Sequence (P for interaction = 0.013) and Rey Auditory Verbal Learning Test immediate recall (P for interaction = 0.005). Better performance in these 2 tests was associated with vitamin B-12 in APOE {epsilon}4 carriers but not in APOE {epsilon}4 noncarriers. Conclusion: The association between vitamin B-12 and cognitive function was moderated by APOE {epsilon}4 status.

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