Long-term effects of giving nursing home residents bread fortified with 125 µg (5000 IU) vitamin D3 per daily serving  

Oleh:

Mocanu, Veronica ; Stitt, Paul A ; Costan, Anca Roxana

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The American Journal of Clinical Nutrition vol. 89 no. 04 (Apr. 2009), page 1132.
Topik: Nutritional support

Ketersediaan

Perpustakaan FK Nomor Panggil: A07.K.2009.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Background: In older adults, a serum 25-hydroxyvitamin D [25(OH)D] concentration >75 nmol/L lowers the risk of fracture. An oral intake of 125 µg (5000 IU) vitamin D3/d may be required to achieve this target. Objective: The objective was to characterize the safety and efficacy of fortifying bread with a biologically meaningful amount of vitamin D3. Design: In a single-arm design, 45 nursing home residents consumed one bun daily that had been fortified with 125 µg (5000 IU) vitamin D3 and 320 mg elemental calcium. Results: The initial mean (±SD) serum 25(OH)D concentration was 28.5 ± 10.8 nmol/L. After 12 mo, the 25(OH)D concentration was 125.6 ± 38.8 nmol/L, and it exceeded 74 nmol/L in 92% of the patients. At every 3-mo follow-up, serum parathyroid hormone was lower than at baseline (P = 0.001). No changes in serum calcium or cases of hypercalcemia were observed at the follow-up assessments. Both mean total urinary calcium and the mean urinary calcium-creatinine ratio increased from baseline at one follow-up time point (P < 0.05). Between baseline and the 12-mo visit, z scores for bone mineral density at the lumbar spine and the hip both increased significantly (P < 0.001). Conclusions: Fortification of bread with much more vitamin D than used previously produced no evident adverse effects on sun-deprived nursing home residents and improved bone density measures. Fortification of bread with 5000 IU vitamin D3/d provided reasonable assurance that vitamin D–deficient older adults attained a serum 25(OH)D concentration greater than the desirable objective of >75 nmol/L.

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