Association between n–3 fatty acid consumption and ventricular ectopy after myocardial infarction  

Oleh:

Smith, Patrick J ; Blumenthal, James A. ; Babyak, Michael A ; Georgiades, Anastasia

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The American Journal of Clinical Nutrition vol. 89 no. 05 (May 2009), page 1315.

Ketersediaan

Perpustakaan FK Nomor Panggil: A07.K.2009.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Background: n–3 (omega-3) Fatty acids are associated with a reduced risk of cardiovascular disease; however, the relation between dietary intake of n–3 fatty acids and ventricular arrhythmias has not been investigated among acute post-myocardial infarction (AMI) patients—a group at elevated risk of malignant arrhythmias. Objective: The objective was to examine the association between n–3 fatty acid consumption and ventricular ectopy among AMI patients. Design: In 260 AMI patients, dietary intake of n–3 fatty acids was assessed by using the Harvard food-frequency questionnaire, and ventricular ectopy was estimated from 24-h electrocardiograph recordings. Results: A greater intake of n–3 fatty acids (eicosapentaenoic acid + docosahexaenoic acid + docosapentaenoic acid + -linolenic acid) was associated with lower ventricular ectopy (ß = –0.35, P = 0.011), and this effect remained after cardiovascular comorbidities were controlled for (ß = –0.47, P = 0.003). Higher concentrations of both marine-based (eicosapentaenoic acid + docosahexaenoic acid) (ß = –0.21, P = 0.060) and plant-based ( -linolenic acid) (ß = –0.33, P = 0.024) fatty acids remained associated with lower ventricular ectopy after cardiovascular comorbidities were controlled for. Conclusion: These findings extend existing evidence linking n–3 fatty acid consumption to a reduced risk of ventricular arrhythmias by showing that a greater intake of n–3 fatty acids may be associated with low ventricular ectopy among AMI patients.

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