MDM2 309 polymorphism is associated with missed abortion  

Oleh:

Yan, Fang ; Beihua, Kong

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Human Reproduction vol. 24 no. 06 (Jun. 2009), page 1346.
Topik: missed abortion/MDM2/polymorphism/pregnancy

Ketersediaan

Perpustakaan FK Nomor Panggil: H07.K.2009.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

BACKGROUND: In this study, we assessed whether the single nucleotide polymorphism in the murine double minute 2 (MDM2) promoter (SNP309) was associated with the occurrence of missed abortion. METHODS: Genotyping of MDM2 SNP309 polymorphism was conducted by polymerase chain reaction-restriction fragment length polymorphism with blood and villous samples from 95 women diagnosed as having 1st trimester missed abortion. RESULTS: The MDM2 SNP309 G/G genotype was associated with a higher risk of missed abortion compared with the T/T+ T/G genotype in blood (P = 0.010; odds ratio (OR): 2.164; 95% confidence interval (CI): 1.207–3.878) and villous samples (P = 0.043; OR: 2.767; 95% CI: 1.092–7.011). CONCLUSIONS: The MDM2 SNP309 G/G genotype may be a genetic risk factor for missed abortion.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali