Nutritional Intervention To Prevent (NIP) Type 1 Diabetes A Pilot Trial  

Oleh:

Chase, H. Peter ; Lescheck, Ellen ; Rafkin-Mervis, Lisa E. ; Krause-Steinrauf, Heidi ; Chritton, Sonia ; Asare, Smita M. ; Adams, Sara ; Skyler, Jay S. ; Clare-Salzler, Michael

Jenis: Article from Article
Dalam koleksi: ICAN: Infant, Child, & Adolescent Nutrition vol. 1 no. 2 (Apr. 2009), page 98-107.
Topik: diabetes (type 1 and 2); chronic disease management; prevent type 1; nutritional intervention
Fulltext: 98.pdf (338.35KB)

Isi artikel

The objective of this study was to describe a pilot trial of using an omega-3 fatty acid (docosahexaenoic acid [DHA]) to prevent islet cell autoimmunity in infants with an increased risk for developing type 1 diabetes (T1D). Infants from pregnant mothers who either have T1D (or the father or a previous child has T1D) and who entered the study in the third trimester or infants younger than age 5 months having a first-degree family member with T1D were eligible for the study. Infants from either group also had to have an increased genetic (HLA) risk for T1D (or multiple first-degree relatives with T1D) to be eligible. The study is a multicenter, 2-arm, randomized, doublemasked clinical trial that will last 4 years (1 year of recruitment and 3 years of treatment). Treatment with DHA (or control) began in the last trimester of pregnancy or in the first 5 months after birth. Inflammatory mediators, including cytokines, chemokines, eicosanoids, and C-reactive protein, are being measured along with fatty acids in maternal and infant blood. Ninety-eight infants were enrolled (41 during pregnancy and 57 in the 5 months after birth). HLA results of the 97 eligible infants (1 infant had a protective 0602 allele and was thus ineligible) showed that 90 have DR3 and/or DR4. Seven infants were enrolled without DR3/4 but who instead had multiple first-degree relatives with T1D. Compliance has been excellent, and no families have discontinued participation. Intervention trials in this high-risk group are feasible but require significant effort to identify potential participants.

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