Detail Kaempferia pandurata Roxb. inhibits Porphyromonas gingivalis supernatant-induced matrix metalloproteinase-9 expression via signal transduction in human oral epidermoid cells (article of Journal of Ethno-Pharmacology, Vol. 123 No. 2, June 2009 p.315–324) Bibliografi Author: Yanti ; Anggakusuma ; Gwon, Song-Hui ; Hwang, Jae-Kwan Topik: Kaempfeha Pandurata Roxb.; Matrix Metalloproteinase-9 Inhibitor; Mitogen-Activated Protein Kinase; Porphyromonas Gingivalis Supernatant; Human Oral Epidermoid Cell; JABFUNG-YANTI-2018-01 Bahasa: (EN )     Penerbit: Elsevier     Tempat Terbit: London    Tahun Terbit: 2009     Jenis: Article - diterbitkan di jurnal ilmiah internasional Fulltext: Kaempferia Pandurata Roxb. Inhibits Porphyromonas Gingivalis Supernatant.pdf (4.74MB; 4 download) 2009_JOE_TEMUKUNCI.pdf (1,017.83KB; 3 download) [Informasi yang berkaitan dengan koleksi ini di internet] Abstract Ethnopharmacological relevance: Kaempferia pandurata Roxb., An edible tropical medicinal plant (Zingib-eraceae), has been traditionally used to treat dental caries. However, its efficacy on inhibition of matrix metalloproteinase (MMP)-9 for preventing periodontal inflammation has been rarely studied to date. Aim of the study: This present study was focused to investigate the effects of the ethanolic extract of Kaempferia pandurata Roxb. on inhibition of Porphyromonas gingivalis supernatant-induced MMP-9 expression through activation of mitogen-activated protein kinase (MAPK) signaling pathways in human oral epidermoid KB cells. Materials and methods: MMP-9 expression and its signaling pathways in KB cells induced by Porphyromonas gingivalis supernatant were determined by gelatin zymogram, Western blotting and reporter gene assays. Results: Kaempferia pandurata significantly decreased MMP-9 expression at both protein and mRNA levels in a close dependent manner. Kaempferia pandurata interfered Porphyromonas gingivalis supernatant-induced MMP-9 expression in KB cells by down regulating MAPK phosphorylation (extracellular signal-related kinase 1/2, p38 kinase and c-Jun N-terminal kinase). inhibiting transeriptional expression (Elk1. c-Jun and c-Fos). and blocking AP-1 and NF-KB activities. Conclusions: Kaempferia pandurata could be employed as a candidate for MMP-9 inhibitor with therapeutic potential for treatment of periodontal inflammation. Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Lihat Sejarah Pengadaan  Konversi Metadata   Kembali

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