Detail Splenic marginal zone Lymphoma: proposal of new diagnostic and prognostic markers identified after tissue and cDNA microarray analysis (in Blood, 106) Bibliografi Author: Ruiz-Ballesteros, Elena ; Mollejo, Manuela ; Rodriguez, Antonia ; Camacho, Francisca I ; Algara, Patrocinio ; Martinez, Nerea ; Pollán, Marina ; Sanchez-Aguilera, Abel ; Menarguez, Javier ; Campo, Elias ; Martinez, Pedro ; Mateo, Marisol ; Piris, Miguel A Topik: cDNA microarray Bahasa: (EN )    Edisi: Sep 2005     Penerbit: American Society of Hematology     Tempat Terbit: Washington DC    Tahun Terbit: 2010     Jenis: Article - diterbitkan di jurnal ilmiah internasional Fulltext: 2004-10-3898v1.pdf (567.69KB; 0 download) Abstract Splenic marginal zone lymphoma (SMZL) is a newly recognized lymphoma type whose precise molecular pathogenesis is still essentially unknown. This hampers differential diagnosis with other small B-cell malignancies. With the aim of characterizing this tumor more comprehensively, and of identifying new diagnostic and prognostic markers, we performed cDNA microarray expression profiling and tissue microarray (TMA) immunohistochemical studies in a relatively large series of 44 SMZLs. The results were related to IgVH mutational status and clinical outcome. SMZLs display a largely homogenous signature, implying the existence of a single molecular entity. Of the genes deregulated in SMZLs, special mention may be made of the genes involved in BCR signaling, TNF signaling and NF-?B activation, such as SYK, BTK, BIRC3, TRAF3 and LTB. Other genes observed were SELL and LPXN, which were highly expressed in spleen, and lymphoma oncogenes, such as ARHH and TCL1. In contrast, the genes CAV1, CAV2 and GNG11 located in 7q31, a commonly deleted area, were downregulated in the entire series. A comparison with the genes comprising the signature of other small B-cell lymphomas identified three genes whose expression distinguishes SMZL, namely ILF1, Senataxin and CD40. Shorter survival was associated with CD38 expression, naïve IgVH genes and the expression of a set of NF-?B pathway genes, including TRAF5, REL and PKC alpha. Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Lihat Sejarah Pengadaan  Konversi Metadata   Kembali

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