Detail Identification of signature genes by microarray for acute myeloid leukemia without maturation and acute promyelocytic leukemia with t(15;17)(q22;q12)(PML/RAR) (in INTERNATIONAL JOURNAL OF ONCOLOGY 23: Bibliografi Author: Morikawa, Jun ; Li, Huai ; Kim, Seungchan ; Nishii, Kazuhiro ; Ueno, Satoshi ; Suh, Edward ; Dougherty, Edward ; Shmulevich, Ilya ; Shiku, Hiroshi ; Zhang, Wei ; Kobayashi, Tohru Topik: Acute Myeloid Leukemia Without Maturation; Acute Promyelocytic Leukemia With T(15; 17)(Q22; Q12)(Pml/Rara); Cdna Microarray; Gene Expression Profiling Bahasa: (EN )     Tahun Terbit: 2003     Jenis: Article - diterbitkan di jurnal ilmiah internasional Fulltext: Identification of signature genes by microarray.pdf (94.61KB; 1 download) Abstract Acute myeloid leukemia (AML) has distinct subgroups characterized by different maturation and specific chromosomal translocation. In order to gain insight into the gene expression activities in AML, we carried out a gene expression profiling study with 21 AML samples using cDNA microarrays, focusing on acute promyelocytic leukemia with specific translocation t(15;17)(q22;q12) [French-American- British or FAB-M3 with t(15;17)] and AML without maturation (FAB-M1) characterized by morphologically and phenotypically immature AML blasts and no recurrent chromosomal abnormalities. Using a multivariate ?-classifier algorithm, we identified 33 strong feature genes that distinguish FAB-M3 with t(15;17) from other AML samples, and 24 strong feature genes that classify FAB-M1. A direct comparison between FAB-M3 with t(15;17) and FAB-M1 led to selection of 13 strong feature genes. Those genes include some known to be related to leukemogenesis and cell differentiation. RIN1, a gene in the ras pathway, was up-regulated in FAB-M3 with t(15;17). Growth factor-binding protein 2 gene was downregulated in FAB-M1. Huntingtin gene was up-regulated in FAB-M1. Others include syndecan 4, interleukin-2 receptor ß, Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Lihat Sejarah Pengadaan  Konversi Metadata   Kembali

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