Detail Identification of c-Myc Responsive Genes Using Rat cDNA Microarray (in Cancer Research 60) Bibliografi Author: Guo, Qingbin M. ; Malek, Renae L. ; Kim, Sunkyu ; Chiao, Chia ; He, Mei ; Ruffy, Mauro ; Sanka, Krishna ; Lee, Norman H. ; Dang, Chi V. ; Liu, Edison T. Topik: cDNA Microarray; Northern Hybridization; c-Myc Responsive Genes Bahasa: (EN )    Edisi: Nov 2000     Penerbit: American Association for Cancer Research     Tempat Terbit: Philadelphia    Tahun Terbit: 2000     Jenis: Article - diterbitkan di jurnal ilmiah internasional Fulltext: 5922.pdf (221.39KB; 0 download) [Informasi yang berkaitan dengan koleksi ini di internet] Abstract c-Myc functions through direct activation or repression of transcription. Using cDNA microarray analysis, we have identified c-Myc-responsive genes by comparing gene expression profiles between c-myc null and c-myc wild-type rat fibroblast cells and between c-myc null and c-myc null cells reconstituted with c-myc. From a panel of 4400 cDNA elements, we found 198 genes responsive to c-myc when comparing wild-type or reconstituted cells with the null cells. The plurality of the named c-Myc-responsive genes that were up-regulated, including 30 ribosomal protein genes, are involved in macro-molecular synthesis and metabolism, suggesting a major role of c-Myc in the regulation of protein synthetic and metabolic pathways. When ectopically overexpressed, c-Myc induced a different and smaller set of c-Myc-responsive genes as compared with the physiologically expressed c-Myc condition. Thus, these results from expression profiling suggest a new primary function for c-Myc and raise the possibility that the physiological and transforming functions of c-myc may be separable. Kajian editorial Advances in Brief Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Lihat Sejarah Pengadaan  Konversi Metadata   Kembali

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