Detail Disease fingerprinting with cDNA microarrays reveals distinct gene expression profiles in lethal type 1 and type 2 cytokine-mediated inflammatory reactions (The FASEB Journal Vol.15) Bibliografi Author: Hoffmann, Karl F. ; McCarty, Thomas C. ; Segal, David H. ; Chiaramonte, Monica ; Hesse, Matthias ; Davis, Eric M. ; Cheever, Allen W. ; Meltzer, Paul S. ; Morse III, Herbert C. ; Wynn, Thomas A. Topik: Schistosoma mansoni; Disease Fingerprinting; cDNA Microarrays Bahasa: (EN )    Edisi: Nov 2001     Penerbit: The Federation of American Societies for Experimental Biology     Tempat Terbit: Bethesda    Tahun Terbit: 2001     Jenis: Article - diterbitkan di jurnal ilmiah internasional Fulltext: 2545.pdf (345.73KB; 0 download) [Informasi yang berkaitan dengan koleksi ini di internet] Abstract In this study, we addressed the hypothesis that severe infection-induced liver disease can develop via two distinct but equally deleterious genetic programs depending on the dominant type 1 or type 2 immunological phenotype. By using murine cDNA microarrays, cytokine-deficient mice, and confirmatory biological assays, we identified gene expression profiles that associate with lethal type 1 and type 2 cytokine polarized immune responses and uncovered the contributions of previously unappreciated disease mechanisms to pathogenesis during infection with the parasitic trematode Schistosoma mansoni. Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Lihat Sejarah Pengadaan  Konversi Metadata   Kembali

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