Detail Toxicity and Tissue Distribution of Magnetic Nanoparticles in Mice (in Toxicological Sciences 89(1)) Bibliografi Author: Kim, Jun Sung ; Yoon, Tae-Jong ; Yu, Kyeong Nam ; Kim, Byung Gul ; Park, Sung Jin ; Kim, Hyun Woo ; Lee, Kee Ho ; Park, Seung Bum ; Lee, Jin-Kyu ; Cho, Myung Haing Topik: Magnetic Nanoparticles; Blood-Brain Barrier; Nanotechnology Bahasa: (EN )    Edisi: Oct 2005     Penerbit: Oxford University Press     Tempat Terbit: London    Tahun Terbit: 2006     Jenis: Article - diterbitkan di jurnal ilmiah internasional Fulltext: 338.pdf (2.26MB; 0 download) [Informasi yang berkaitan dengan koleksi ini di internet] Abstract The development of technology enables the reduction of material size in science. The use of particle reduction in size from micro to nanoscale not only provides benefits to diverse scientific fields but also poses potential risks to humans and the environment. For the successful application of nanomaterials in bioscience, it is essential to understand the biological fate and potential toxicity of nano-particles. The aim of this study was to evaluate the biological distribution as well as the potential toxicity of magnetic nano-particles to enable their diverse applications in life science, such as drug development,protein detection,and gene delivery.Werecently synthesized biocompatible silica-overcoated magnetic nanopar-ticles containing rhodamine Bisothiocyanate (RITC) withinasilica shell of controllable thickness [MNPs@SiO2(RITC)]. In this study, the MNPs@SiO2(RITC) with 50-nm thickness were used as a model nanomaterial. After intraperitoneal administration of MNPs@ SiO2(RITC) for 4 weeks into mice, the nanoparticles were detected in the brain, indicating that such nanosized materials can penetrate blood–brain barrier (BBB) without disturbing its function or producing apparent toxicity. After a 4-week observation, MNPs@ SiO2(RITC) was still present in various organs without causing apparent toxicity. Taken together, our results demonstrated that magnetic nanoparticles of 50-nm size did not cause apparent toxicity under the experimental conditions of this study. Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Lihat Sejarah Pengadaan  Konversi Metadata   Kembali

Copyright © 2006, 2007 Unika Atma Jaya, all rights reserved