Body mass index over the adult life course and cognition in late midlife: the Whitehall II Cohort Study  

Oleh:

Sabia, Sverine ; Kivimaki, Mika ; Shipley, Martin J. ; Marmot, Michael G. ; Singh-Manoux, Archana

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The American Journal of Clinical Nutrition vol. 89 no. 02 (Feb. 2009), page 601.

Ketersediaan

Perpustakaan FK Nomor Panggil: A07.K.2009.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Background: The extent to which cognition in late midlife is influenced by lifetime obesity is unclear. Objective: We examined the association between body mass index (BMI) over the adult life course and cognition in late midlife and assessed the cumulative effects of obesity and underweight. Design: Data from the Whitehall II Study were examined. BMI at 25 y (early adulthood) was self-reported at phase 1 and was measured in early midlife (mean age = 44 y; phase 1) and in late midlife (mean age = 61 y; phase 7). Cognition (n = 5131) was assessed in late midlife (phase 7) by using the Mini-Mental State Examination and tests of memory and executive function, all of which were standardized to T scores (mean ± SD: 50 ± 10). Results: Both underweight and obesity were associated with lower cognition in late midlife and with early adulthood, early midlife, and late midlife measures of BMI. Being obese at 2 or 3 occasions was associated with lower Mini-Mental State Examination scores and scores of memory and executive function in analyses adjusted for age, sex, and education [difference (95% CI) in mean T scores compared with normal-weight group: –1.51 (–2.77, –0.25), –1.27 (–2.46, –0.07), and –1.35 (–2.45, –0.24), respectively]. Participants who were underweight at 2 occasions from early adulthood to late midlife had lower executive function [difference (95% CI) in mean T score: –4.57 (–6.94, –2.20)]. A large increase in BMI from early to late midlife was associated with lower executive function. Conclusions: Long-term obesity and long-term underweight in adulthood are associated with lower cognitive scores in late midlife. Public health messages should promote a healthy weight at all ages.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali