Effects of a low-salt diet on flow-mediated dilatation in humans  

Oleh:

Dickinson, Kacie M ; Keogh, Jennifer B. ; Clifton, Peter M.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The American Journal of Clinical Nutrition vol. 89 no. 02 (Feb. 2009), page 485.

Ketersediaan

Perpustakaan FK Nomor Panggil: A07.K.2009.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Background: The effect of salt reduction on vascular function, assessed by brachial artery flow-mediated dilatation (FMD), is unknown. Objective: Our aim was to compare the effects of a low-salt (LS; 50 mmol Na/d) diet with those of a usual-salt (US; 150 mmol Na/d) diet on FMD. Design: This was a randomized crossover design in which 29 overweight and obese normotensive men and women followed an LS diet and a US diet for 2 wk. Both diets had similar potassium and saturated fat contents and were designed to ensure weight stability. After each intervention, FMD, pulse wave velocity, augmentation index, and blood pressure were measured. Results: FMD was significantly greater (P = 0.001) with the LS diet (4.89 ± 2.42%) than with the US diet (3.37 ± 2.10%), systolic blood pressure was significantly (P = 0.02) lower with the LS diet (112 ± 11 mm Hg) than with the US diet (117 ± 13 mm Hg), and 24-h sodium excretion was significantly lower (P = 0.0001) with the LS diet (64.1 ± 41.3 mmol) than with the US diet (156.3 ± 56.7 mmol). There was no correlation between change in FMD and change in 24-h sodium excretion or change in blood pressure. No significant changes in augmentation index or pulse wave velocity were observed. Conclusions: Salt reduction improves endothelium-dependant vasodilation in normotensive subjects independently of the changes in measured resting clinic blood pressure. These findings suggest additional cardioprotective effects of salt reduction beyond blood pressure reduction

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali