Threonine requirement of parenterally fed postsurgical human neonates  

Oleh:

Chapman, Karen P ; Courtney-Martin, Glenda ; Moore, Aideen M ; Ball, Ronald O. ; Pencharz, Paul B.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The American Journal of Clinical Nutrition vol. 89 no. 01 (Jan. 2009), page 134.
Topik: Energy and protein metabolism

Ketersediaan

Perpustakaan FK Nomor Panggil: A07.K.2009.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Background: The threonine requirement of human neonates who receive parenteral nutrition (PN) has not been determined experimentally. Objective: The objective was to determine the parenteral threonine requirement for human neonates by using the minimally invasive indicator amino acid oxidation technique with L-[1-13C]phenylalanine as the indicator amino acid. Design: Nine postsurgical neonates were randomly assigned to 16 threonine intakes ranging from 10 to 100 mg · kg–1 · d–1. Breath and urine samples were collected at baseline and at plateau for 13CO2 and amino acid enrichment, respectively. The mean threonine requirement was determined by applying a 2-phase linear regression crossover analysis to the measured rates of 13CO2 release (F13CO2) and L-[1-13C]phenylalanine oxidation. Results: The mean threonine parenteral requirement determined by using phenylalanine oxidation was 37.6 mg · kg–1 · d–1 (upper and lower confidence limits, respectively: 29.9 and 45.2 mg · kg–1 · d–1) and by using F13CO2 oxidation was 32.8 mg · kg–1 · d–1 (upper and lower confidence limits, respectively: 29.7 and 35.9 mg · kg–1 · d–1). Graded intakes of threonine had no effect on phenylalanine flux. Conclusion: This is the first study to report on the threonine requirement for human neonates receiving PN. We found that the threonine requirement for postsurgical PN-fed neonates is 22–32% of the content of threonine that is presently found in commercial PN solutions (111–165 mg · kg–1 · d–1).

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