Combined enteral infusion of glutamine, carbohydrates, and antioxidants modulates gut protein metabolism in humans  

Oleh:

Coeffier, Moise ; Claeyssens, Sophie ; Lecleire, Stephane ; Leblond, Jonathan ; Coquard, Aude

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The American Journal of Clinical Nutrition vol. 88 no. 05 (Nov. 2008), page 1284.
Topik: glutamine; carbohydrates; antioxidants;

Ketersediaan

Perpustakaan FK Nomor Panggil: A07.K.2008.04 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Background: Available data suggest that nutrients can affect intestinal protein metabolism, which contributes to the regulation of gut barrier function. Objective: We aimed to assess whether an oral nutritional supplement (ONS) containing glutamine (as the dipeptide Ala-Gln), carbohydrates, and antioxidants would modulate duodenal protein metabolism in healthy humans. Design: Thirty healthy control subjects were included and, over a period of 5 h, received by nasogastric tube either saline or ONS providing 11.7 kcal/kg as 0.877 g Ala-Gln/kg, 3.9 g carbohydrates/kg, and antioxidants (29.25 mg vitamin C/kg, 9.75 mg vitamin E/kg, 195 µg ß-carotene/kg, 5.85 mg Se/kg, and 390 µg Zn/kg) or glutamine (0.585 g/kg, 2.34 kcal/kg). Simultaneously, a continuous intravenous infusion of L-[1-13C]-leucine was done until endoscopy. Leucine enrichment was assessed by using gas chromatography–mass spectrometric analysis, and mucosal fractional synthesis rate was calculated by using intracellular amino acid enrichment as precursor. Mucosal proteolytic pathways were also evaluated. Results: ONS infusion resulted in a doubling increase (P < 0.01) of duodenal fractional synthesis rate and a significant (P < 0.05) decrease in cathepsin D–mediated proteolysis compared with saline, whereas proteasome and Ca2+-dependent activities were unaffected. ONS infusion significantly (P < 0.01) decreased duodenal glutathione but not glutathione disulfide concentrations or the ratio of glutathione to glutathione disulfide. Insulinemia increased after ONS infusion, whereas plasma essential amino acids decreased. Infusion of glutamine alone did not reproduce ONS effects. Conclusions: ONS infusion improves duodenal protein balance in healthy humans. Further investigations are needed to study the origin of these effects and to evaluate ONS supply in stressed persons.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali