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ArtikelVirus Infection, Asthma, and Chronic Obstructive Pulmonary Disease  
Oleh: Djukanovic, Ratko ; Gadola, Stephan D.
Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The New England Journal of Medicine (keterangan: ada di Proquest) vol. 359 no. 19 (Nov. 2008), page 2062.
Ketersediaan
  • Perpustakaan FK
    • Nomor Panggil: N08.K.2008.06
    • Non-tandon: 1 (dapat dipinjam: 0)
    • Tandon: tidak ada
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Isi artikelBoth asthma and chronic obstructive pulmonary disease (COPD) are characterized by chronic inflammation of the airways. This inflammation is accompanied by increased mucus production and an excessive propensity of the airway smooth musculature to contract in response to exogenous stimuli, a phenomenon that is termed airway hyperreactivity. It has long been speculated but not clearly shown that viruses are involved in the development of these diseases. Kim and colleagues1 recently provided grist for this mill with their observation of chronic goblet-cell metaplasia and airway hyperreactivity in mice after virus infection. According to the prevailing paradigm, major-histocompatibility-complex (MHC) class II–dependent CD4+ . . .
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