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Inherited Susceptibility to Common Cancers
Oleh:
Foulkes, William D.
Jenis:
Article from Journal - ilmiah internasional
Dalam koleksi:
The New England Journal of Medicine (keterangan: ada di Proquest) vol. 359 no. 20 (Nov. 2008)
,
page 2143.
Ketersediaan
Perpustakaan FK
Nomor Panggil:
N08.K.2008.06
Non-tandon:
1 (dapat dipinjam: 0)
Tandon:
tidak ada
Lihat Detail Induk
Isi artikel
Rare, large families with multiple cases of early-onset cancer affecting several generations provide clear evidence that inherited factors are important causes of cancer.1 The range of cancers, the age at onset, and the number of generations affected all suggest familial risk. In this review, I discuss the five cancers in the United States that are associated with the highest number of deaths: lung, breast, colorectal, prostate, and pancreatic cancer. In the late 1980s and early 1990s, numerous cancer susceptibility genes were identified, including those for breast and colorectal cancer (Glossary and Table 1). These genes confer high relative risks . . .
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