How Is a Statistical Link Established Between a Human Outcome and a Genetic Variant?  

Oleh:

Guang, Guo ; Adkins, Daniel E.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Sociological Methods & Research (SMR) vol. 37 no. 02 (Nov. 2008), page 201-226.
Topik: Society and Genetics; Behavior Genetics; Association Studies; Linkage Analysis
Fulltext: SMR vol.37 no.2 p.201 Nov 2008_win.pdf (643.9KB)

Ketersediaan

Perpustakaan PKPM Nomor Panggil: S28 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

The objective of this article is to provide a nontechnical and intuitive introduction to the basic concepts and techniques that are used to establish statistical connections between genetic variants and human phenotypes. Depressive symptoms and delinquent behaviors that are of interest to sociologists are a subset of such human phenotypes. This article focuses on basic linkage analysis and association studies, the essential ideas behind the methods, and a very limited amount of molecular genetics needed for understanding the ideas. The article is written with those social scientists in mind who are interested in the topic but not yet ready to engage the vast and rapidly developing primary literature (journal articles).

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