A 9-cis ß-Carotene–Enriched Diet Inhibits Atherogenesis and Fatty Liver Formation in LDL Receptor Knockout Mice  

Oleh:

Harari, Ayelet ; Harats, Dror ; Marko, Daniella ; Cohen, Hofit ; Barshack, Iris

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: JN: The Journal of Nutrition vol. 138 no. 10 (Oct. 2008), page 1923.
Topik: Nutrition and Disease

Ketersediaan

Perpustakaan FK Nomor Panggil: J42.K.2008.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Our aim was to study the effect of 9-cis ß-carotene–rich powder of the alga Dunaliella bardawil on lipid profile, atherogenesis, and liver steatosis in high-fat diet–fed LDL receptor knockout mice. In 4 sets of experiments, mice were distributed into the following groups: control, fed an unfortified diet; Dunaliella 50, fed a diet composed of 50% 9-cis and 50% all-trans ß-carotene; Dunaliella 25, fed a diet containing 25% 9-cis and 75% all-trans ß-carotene; ß-carotene–deficient Dunaliella, fed ß-carotene–deficient Dunaliella powder; and all-trans ß-carotene, fed a synthetic all-trans ß-carotene. All fortified diets contained 0.6% total ß-carotene. Algal 9-cis ß-carotene was absorbed by the mice and accumulated in the liver. Synthetic all-trans ß-carotene was not converted to 9-cis ß-carotene. Dunaliella 50 inhibited high-fat diet–induced plasma cholesterol elevation by 40–63% and reduced cholesterol concentrations in the atherogenic VLDL and LDL. Atherosclerotic lesion area in mice treated with Dunaliella 50 was 60–83% lower compared with mice fed the high-fat diet alone. ß-Carotene–deficient Dunaliella did not influence plasma cholesterol and atherogenesis, suggesting that ß-carotene is essential for a Dunaliella protective effect. Moreover, by administrating Dunaliella powder containing different levels of 9-cis and all-trans ß-carotene isomers, we found that the effect on plasma cholesterol concentration and atherogenesis is 9-cis-dependent. Dunaliella 50 also inhibited fat accumulation and inflammation in the livers of mice fed a high-fat diet, which was accompanied by reduced mRNA levels of inflammatory genes. These results in mice suggest that 9-cis ß-carotene may have the potential to inhibit atherogenesis in humans.

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