Consumption of purple sweet potato leaves decreases lipid peroxidation and DNA damage in humans  

Oleh:

Chiao-Ming, Chen ; YA-LING, LIN ; C-Y, OLIVER CHEN ; CHING-YUN, HSU ; MING-JER, SHIEH ; Jen-Fang, Liu

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Asia Pacific Journal of Clinical Nutrition (keterangan: ada di Proquest) vol. 17 no. 03 (2008), page 408.
Topik: purple sweet potato leaves; 8-hydroxydeoxyguanosine; polyphenols; total antioxidant status; glutathione

Ketersediaan

Perpustakaan FK Nomor Panggil: A27.K.2008.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Consumption of polyphenols is associated with reduced risk of chronic diseases, possibly via a variety of bio-mechanisms, including antioxidation and anti-inflammation. Purple sweet potato leaves (PSPL) commonly consumed in Asia possess polyphenols. In this study, we aim to investigate antioxidant effect of 200 g/d PSPL containing 902 mg polyphenols in a clinical trial. This randomized, crossover clinical study included 16 healthy adults (7 M, 9 F; aged 20-22 y). After a 1-wk run period, subjects were assigned randomly to receive either PSPL or low polyphenol diet (LPD) for 2 wks, followed by a 2-wk washout period before crossing over to the alternate diet. Fasting blood and 24-h urine samples were collected from each subject at day 0, 7 and 14 of each phase. Our data showed PSPL consumption enhanced urinary total phenol excretion by 24.5% at day 14 as compared to day 0, while the LPD decreased total phenol content in plasma and urine by 3.3 and 16.3%, respectively (p =0.05). Low-density lipoprotein lag time and glutathione concentration in erythrocytes at day 14 was significantly enhanced by 15.0 and 33.3% by PSPL as compared to day 0, respectively, while their values were not altered by the LPD. Urinary 8-hydoxy-deoxyguanosine (8-OHdG) excretion decreased significantly by PSPL consumptoin by 36.7% at day 7 as compared to day 0, yet unchanged by the LPD (p =0.05). In conclusion, our results suggest that polyphenols in 200 g PSPL were bioavailable and could enhance antioxidant defense and decrease oxidative stress in young healthy people.

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