Detail Biological Activity of rhBMP-2 Released From PLGA Microspheres   Oleh:  Oldham, J. B. ; Lu, L. ; Zhu, X. ; Porter, B. D. ; Hefferan, T. E. ; Larson, D. R. ; Currier, B. L. ; Mikos, A. G. ; Yaszemski, M. J. Jenis: Article from Bulletin/Magazine Dalam koleksi: Journal of Biomechanical Engineering vol. 122 no. 3 (2000), page 289-292. Topik: BIOLOGICAL DIVERSITY; biological activity; microspheres Ketersediaan Perpustakaan Pusat (Semanggi) Nomor Panggil: JJ52.1 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada     Lihat Detail Induk Isi artikel Human recombinant bone morphogenetic protein - 2 (rhBMP - 2) has been proven effective in stimulating the regeneration of bone in both skeletal and extraskeletal locations. Through encapsulation within, and release from, biodegradable poly(DL - lactic - co - glycolic acid) (PLGA) microspheres, a proven vehicle for sustained delivery of various proteins, the local concentrations of rhBMP - 2 could be maintained at optimal levels to stimulate bone regeneration and remodeling at the site of healing in diverse clinical settings. Thus the purpose of this work was to investigate the encapsulation of rhBMP - 2 in PLGA microspheres and its biologic activity upon release. Using in vitro tests in simulated body fluids, the effect of rhBMP - 2 released from PLGA microspheres upon osteoblast cell cultures was found to be statistically similar to the effect produced by positive controls consisting of non encapsulated aqueous rhBMP - 2 in simulated body fluids. This clarifies an important step in skeletal tissue engineering strategies aimed at the use of encapsulated rhBMP -2 to stimulate bone regeneration and remodeling. Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Kembali

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