Vitamin A equivalence of spirulina ß-carotene in Chinese adults as assessed by using a stable-isotope reference methodVitamin A equivalence of spirulina ß-carotene in Chinese adults as assessed by using a stable-isotope reference methodVitamin A equivalence of spirulina ß-carotene in Chinese adults as assessed by using a stable-isotope reference method  

Oleh:

Jie, Wang ; Yin, Wang ; Zhixu, Wang ; Lei, Li ; Jian, Qin

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The American Journal of Clinical Nutrition vol. 87 no. 06 (Jun. 2008), page 1731.
Topik: Vitamins; minerals; and phytochemicals

Ketersediaan

Perpustakaan FK Nomor Panggil: A07.K.2008.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Background: Spirulina is a high-protein food supplement that contains carotenoids. Objective: The objective of the study was to determine the vitamin A equivalence of spirulina ß-carotene in humans. Design: Spirulina was grown in a 23 atom% 2H2O cultural solution. Spirulina ß-carotene showed the greatest enrichment as [2H10]trans ß-carotene. Ten healthy Chinese men with a mean (±SD) serum retinol concentration of 1.7 ± 0.3 µmol/L and a body mass index (in kg/m2) of 23 ± 3 consumed 5.8 µmol [13C10]retinyl acetate in oil as a reference dose with a breakfast containing 13 g fat. One week later, each subject consumed 7.9 µmol trans ß-carotene in spirulina with a breakfast containing 22 g fat. All subjects followed diets low in carotenoid and vitamin A. Forty blood samples were collected from each subject over a span of 56 d. Concentrations and enrichments of retinol and ß-carotene in serum samples were determined by using HPLC and a mass spectrometer. Results: Compared with the serum response to [13C10]retinyl acetate dose, the mean conversion factor of spirulina ß-carotene to retinol was 4.5 ± 1.6 (range: 2.3–6.9) by weight. It was estimated that 80% of the conversion occurred within the first 24 h after spirulina administration. Conclusion: In a group of well-nourished, normal-weight Chinese men following low-vitamin A diets, 4.5 mg spirulina ß-carotene consumed with 22 g fat has the same vitamin A activity as does 1 mg retinyl acetate.

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