Sex differences in the inhibition of {gamma}-tocopherol metabolism by a single dose of dietary sesame oil in healthy subjects  

Oleh:

Frank, Jan ; Lee, Sangeun ; Leonard, Scott W ; Atkinson, Jeffrey K ; Kamal-Eldin, Afaf

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The American Journal of Clinical Nutrition vol. 87 no. 06 (Jun. 2008), page 1723.
Topik: Vitamins; minerals; and phytochemicals

Ketersediaan

Perpustakaan FK Nomor Panggil: A07.K.2008.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Background: {gamma}-Tocopherol has unique properties that may be beneficial in sustaining optimal human health, but hepatic vitamin E metabolism enhances {gamma}-tocopherol turnover. Objective: Our aim was to determine the extent to which dietary sesame lignans alter human {alpha}- and {gamma}-tocopherol metabolism and elimination as carboxyethyl hydroxychromanols (CEHCs). Design: Healthy participants (n = 5 women and 5 men) in a randomized, crossover study (with 4-wk washout) consumed muffins prepared with either corn oil or unrefined sesame oil (sesamin, 94 mg; sesamolin, 42 mg), along with a capsule containing a 1:1 molar ratio of deuterium-labeled d6-{alpha}- and d2-{gamma}-tocopherol acetates ({approx}50 mg each). Plasma and urine were collected up to 72 h; unlabeled and labeled tocopherol and CEHC concentrations were determined by liquid chromatography–mass spectrometry. Results: Sesame oil muffin consumption in men, but not in women, decreased (P < 0.05) areas under plasma d2-{gamma}-CEHC concentration-time curves (area under the curve) and maximum concentrations. However, in both sexes urinary d2-{gamma}-CEHCs were decreased for 24 h following sesame oil muffin consumption. Conclusions: In humans, {gamma}-tocopherol metabolism can be inhibited by the simultaneous consumption of {gamma}-tocopherol and sesame lignans. The observed differences between men and women with respect to vitamin E metabolism warrant further investigation.

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