Detail Mx1 Gene Protects Mice Against the Highly Lethal Human H5N1 Influenza Virus (Report in Cell Cycle 6:19, 2417-2421) Bibliografi Author: Salomon, Rachelle ; Staeheli, Peter ; Kochs, Georg ; Yen, Hui-Ling ; Franks, John ; Rehg, Jerold E. ; Webster, Robert G. ; Hoffmann, Erich Topik: Mx1 Gene; Mice; H5N1 Influenza Virus Bahasa: (EN )    Edisi: October 2007     Penerbit: Landes Bioscience     Tempat Terbit: Austin    Tahun Terbit: 2007     Jenis: Article - diterbitkan di jurnal ilmiah internasional Fulltext: H5N1_3.pdf (1.23MB; 0 download) Abstract We investigated the importance of the host Mx1 gene in protection against highly pathogenic H5N1 avian influenza virus. Mice expressing the Mx1 gene survived infection with the lethal human H5N1 isolate A/Vietnam/1203/04 and with reassortants combining its genes with those of the non-lethal virus A/chicken/Vietnam/C58/04, while all Mx1-/- mice succumbed. Mx1-expressing mice showed lower organ virus titers, fewer lesions, and less pulmonary inflammation. Our data support the hypothesis that Mx1 expression protects mice against the high pathogenicity of H5N1 virus through inhibition of viral polymerase activity ultimately resulting in reduced viral growth and spread. Drugs that mimic this mechanism may be protective in humans. Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Lihat Sejarah Pengadaan  Konversi Metadata   Kembali

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