Patching a Leaky Intestine  

Oleh:

Lencer, Wayne I.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The New England Journal of Medicine (keterangan: ada di Proquest) vol. 359 no. 05 (Jul. 2008), page 526.

Ketersediaan

Perpustakaan FK Nomor Panggil: N08.K.2008.04 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

In patients with protein-losing enteropathy, the intestinal mucosa completely fails to function as a competent barrier separating the body from the outside world. Serum fluids and proteins quickly leak into the stool, causing diarrhea, hypoalbuminemia, and sometimes death. A recent study by Bode and colleagues1 showed that the disease might be related to the loss of heparin sulfate proteins that are normally expressed on intestinal cells. Remarkably, the investigators also showed that the disease can be successfully treated with novel analogues of heparin sulfate. For the intestine to efficiently absorb nutrient solutes, it first has to effectively separate the lamina . . .

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