Detail A natural classification of the basic helix–loop–helix class of btranscription factors (in Proc. Natl. Acad. Sci. USA Vol. 94, pp. 5172–5176, May 1997) Bibliografi Author: Atchley, William R. ; Fitch, Walter M. Topik: Transcription factors; basic Helix–Loop–Helix (bHLH) proteins Bahasa: (EN )     Tahun Terbit: 1997     Jenis: Article - diterbitkan di jurnal ilmiah internasional Fulltext: Atchley & Fitch 1997.pdf (285.15KB; 0 download) Abstract A natural (evolutionary) classification is provided for 242 basic helix–loop–helix (bHLH) motif-containing proteins. Phylogenetic analyses of amino acid sequences describe the patterns of evolutionary change within the motif and delimit evolutionary lineages. These evolutionary lineages represent well known functional groups of proteins and can be further arranged into five groups based on binding to DNA at the hexanucleotide E-box, the amino acid patterns in other components of the motif, and the presencey absence of a leucine zipper. The hypothesized ancestral amino acid sequence for the bHLH transcription factor family is given together with the ancestral sequences of the subgroups. It is suggested that bHLH proteins containing a leucine zipper are not a natural, monophyletic group. Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Lihat Sejarah Pengadaan  Konversi Metadata   Kembali

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