From Darwin's Finches to Canaries in the Coal Mine — Mining the Genome for New Biology  

Oleh:

Hunter, David J. ; Altshuler, David ; Rader, Daniel J.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The New England Journal of Medicine (keterangan: ada di Proquest) vol. 358 no. 26 (Jun. 2008), page 2760.

Ketersediaan

Perpustakaan FK Nomor Panggil: N08.K.2008.03 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

The observations of finches that Charles Darwin made while in the Galapagos contributed to his theory of the origins of interspecies differences, ultimately leading to our understanding of mutation and natural selection as drivers of phenotypic variation. Now, more than 150 years later, genomewide association studies have identified more than 100 new chromosomal regions at which DNA variation influences risk of common human diseases and clinical phenotypes.1 Since previous approaches to identifying genetic causes of common diseases have met with very limited success, this moment constitutes a watershed in the history of genetics in medicine. Although associations with common single-nucleotide . . .

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