Rheological Properties of Cell-Hydrogel Composites Extruding Through Small-Diameter Tips  

Oleh:

Cheng, Jie ; Feng Lin ; Liu, Haixia ; Yan, Yongnian ; Wang, Xiaohong ; Zhang, Renji ; Xiong, Zhuo

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Journal of Manufacturing Science and Engineering vol. 130 no. 2 (Apr. 2008), page 021014.
Topik: Cell Assembly; Bioplotting; Cell Printing; Cell-Hydrogel Composite; Rheological Property

Ketersediaan

Perpustakaan Pusat (Semanggi) Nomor Panggil: JJ93.11 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

To form 3D structures with composites of living cells and hydrogel is now becoming an attractive technology in both bioengineering and manufacturing areas. Variant processes have been presented, most of which are based on the cell composite extrusion and deposition technique. So, the design of cell extrusion nozzle turns into an important phase, and the rheological properties of cell-hydrogel composites act as a key parameter and must be well investigated. In this paper, an entrance pressure detection devide and adaptor for small-diameter tips were developed. With the hypothesis of power law fluid type, the power law constant and coefficient were calculated. As derved from the experimental results, the cell-hydrogel composites (with the maximum cell concentration fo 10^7/ml) show no difference from hydrogel materials in rheological properties. Based on these, the manufacturability of cell-hydrogel composites was discussed. Also, the cell viability, which is another important issue in cell assembly technology, was discussed. The peak percentage (97%) was achieved at the flow rate of 0.5mm^3/s. The extruding duration and the maximum shear stress loaded on cells were considered as two influence mechanisms.

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