Anda belum login :: 20 Jul 2025 11:30 WIB
Home
|
Logon
Hidden
»
Administration
»
Collection Detail
Detail
Study of Impact-Induced Mechanical Effects in Cell Direct Writing Using Smooth Particle Hydrodynamic Method
Oleh:
Wei Wang
;
Huang, Yong
;
Grujicic, Mica
;
Chrisey, Douglas B.
Jenis:
Article from Journal - ilmiah internasional
Dalam koleksi:
Journal of Manufacturing Science and Engineering vol. 130 no. 2 (Apr. 2008)
,
page 021012.
Topik:
Direct Writing
;
Cell
;
Hydrogel
;
Impact
;
Smooth Particle Hydrodynamic Method
Ketersediaan
Perpustakaan Pusat (Semanggi)
Nomor Panggil:
JJ93.11
Non-tandon:
1 (dapat dipinjam: 0)
Tandon:
tidak ada
Lihat Detail Induk
Isi artikel
Biomaterial direct-write technologies have been receiving more and more attention as rapid prototyping innovations in the area of tissue engineering, regenerative medicine, and biosensor/actuator fabrication based on computer-aided designs. However, cell damage due to the mechanical impact during cell direct writing has been observed and is a possible hurdle for broad applications of fragile cell direct writing. The objective of this study is to investigate the impact-induced cell mechanical loading profile in cell landing in terms of stress, acceleration, and maximum shear strain component during cell direct writing using a mesh-free smooth particle hydrodynamic method. Such cell mechanical loading profile information can be used to understand and predict possible impact-induced cell damage. It is found that the cell membrane usually undergoes a relatively severe deformation and the cell mechanical loading profile is dependent on the cell droplet initial velocity and the substrate coating thickness. Two important impact processes may occur during cell direct writing: the first impact between the cell droplet and the substrate coating and the second impact between the cell and the substrate. It is concluded that the impact-induced cell damage depends not only on the magnitudes of stress, acceleration, and/or shear strain but also the loading history that a cell experiences.
Opini Anda
Klik untuk menuliskan opini Anda tentang koleksi ini!
Kembali
Process time: 0 second(s)