Selective Ultrasonic Foaming of Polymer for Biomedical Applications  

Oleh:

Wang, Hai ; Li, Wei

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Journal of Manufacturing Science and Engineering vol. 130 no. 2 (Apr. 2008), page 021004.
Topik: Porous Polymer; High Intensity Focused Ultrasound; Selective Ultrasonic Foaming; Tissue Engineering Scaffold; 3D Cell Culture; Concentration Dependent Diffusion Model

Ketersediaan

Perpustakaan Pusat (Semanggi) Nomor Panggil: JJ93.11 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Biocompatible polymeric material with well-defined, interconnected porous structure plays an important role in many biomedical applications, such as tissue engineering, controlled drug release, biochemical sensing, and 3D cell culture for drug discovery. In this study, a novel fabrication process for porous polymer is developed using high intersity focused ultrasound. This acoustic method is solvent-free and capable of creating interconnected porous structured with varrying topographical features at designed locations. An experimental study on the selective ultrasonic foaming technique is presented in this paper. We investigated the effects of major process variables, including ultrasound power, scanning speed, and gas concentration. Both pore size and interconnectivity of the created porous structures were examined. It was found that the pore size could be controlled with the scanning speed of the ultrasound insonation and that interconnected porous structures could be obtained using a partial saturation procedure. A concentration-dependent gas diffusion model was developed to predict the gas concentration profiles for partially saturated samples. A cell culture study was conducted to examine cell growth behavior in the fabricated porous structures.

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