Detail Object alternation and orbitofrontal system dysfunction in Alzheimer's and Parkinson's disease   Oleh:  Freedman, Morris Jenis: Article from Bulletin/Magazine Dalam koleksi: Brain and Cognition vol. 14 no. 2 (Nov. 1990), page 134-143. Ketersediaan Perpustakaan PKBB Nomor Panggil: 405/BAC/14 Non-tandon: tidak ada Tandon: 1  Lihat Detail Induk Isi artikel Previous performance on measures of frontal system function have suggested prominent orbitofrontal system damage in Alzheimer's disease, but not in Parkinson's dementia. Object alternation (OA), a task sensitive to orbitofrontal system dysfunction in non-human animals, was therefore administered to determine whether this measure would distinguish Alzheimer's from Parkinson's dementia. OA was significantly impaired in Alzheimer's disease compared to Parkinson's dementia, even though both groups were equated for severity of dementia. Although the patients with Parkinson's dementia also showed impairment on OA compared to normals, an error analysis revealed that the performance of the Alzheimer's patients, but not the Parkinson's patients, was characterized by abnormal response perseveration. The marked perseverative deficit in Alzheimer's disease may reflect orbitofrontal system dysfunction whereas the milder, and qualitatively different, deficits in Parkinson's disease may reflect dorsolateral frontal system involvement. @ 1990 Academic Press, Inc. Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Kembali

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