Chemical Immunosuppression in Islet Transplantation — Friend or Foe?  

Oleh:

Chatenoud, Lucienne

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The New England Journal of Medicine (keterangan: ada di Proquest) vol. 358 no. 11 (Mar. 2008), page 1192.

Ketersediaan

Perpustakaan FK Nomor Panggil: N08.K.2008.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Insulin-dependent (type 1) diabetes mellitus is an autoimmune disease caused by the selective destruction of pancreatic beta cells by CD4+ and CD8+ autoreactive T lymphocytes. The induction of effective and sustained beta-cell regeneration represents the holy grail of therapy for this disease. Will it ever be grasped? A provocative study by Nir and colleagues1 suggests that the answer to this fundamental question is yes. The authors based their research on an experimental mouse model carrying a transgene that drives the expression of a beta-cell–targeted "toxic" insult — the diphtheria toxin (DTA). With this model, they showed that massive beta-cell regeneration . . .

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