Diagnosis and Prognosis in Acute Myeloid Leukemia — The Art of Distinction  

Oleh:

Lowenberg, Bob

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The New England Journal of Medicine (keterangan: ada di Proquest) vol. 358 no. 18 (May 2008), page 1960.

Ketersediaan

Perpustakaan FK Nomor Panggil: N08.K.2008.03 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

The days when the microscope was the principal tool for classifying the various forms of acute myeloid leukemia (AML) and predicting the outcome of affected patients seem long past. The discovery, during the past 15 years, of acquired mutations and alterations in gene expression in the leukemic cells in all varieties of AML has not only changed the role of the microscope in diagnosing leukemia but also influenced the management of these diseases and how we think about their causes. Genomic alterations in AML affect the function of signaling molecules, transcription factors, and growth-factor receptors and also determine the phenotype . . .

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